METABOLOMICS
OUR TECHNOLOGY

MTI has an unique three-step R&D platform for the development of metabolomics based diagnostic tests.

  • Clinical data collection
  • Biomarker
  • Diagnostic test development and validation

MTI has committed and dedicated research and development facilities through contractual and collaborative agreements with the University of Alberta, Centre of Excellence in Gastrointestinal Inflammatory and Immunity Research (CEGIIR), Northern Alberta Clinical Trials Research Centre (NACTRC), National High Field Nuclear Magnetic Resonance Centre (NANUC), The Metabolomics Innovation Centre (TMIC) and Chenomx Inc. These facilities provide MTI the access to the resources and experts required for a successful completion of a metabolomic based R&D projects, including basic research laboratory facilities and supplies, clinical trial facilities and supplies, NMR facilities, LCMS facilities, and machine intelligence.

BASIC RESEARCH LABORATORY FACILITIES AND SUPPLIES

MTI's in-house research resources include the use of the Center of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR). CEGIIR is funded through a $22 million award from the Canadian Foundation for Innovation and is a unique collaborative joint effort of 35 internationally recognized scientists and clinicians. CEGIIR provides infrastructure support including research and clinical space, equipment, computing network and meeting spaces for a number of its team members. CEGIIR's basic research space is comprised of approximately 1,175 m2 of space on floor 7 of the Katz Group Health Research Facility. This space is comprised of (a) main office area, (b) principal investigator labs, (c) support facilities, (d) microbiology facility, (e) tissue bank facility and (f) The Applied Genomics Centre (TAGC). In addition to the basic research space in the Katz Group Health Research Facility, CEGIIR has approximately 2,000 m2 of faculty office space and dry lab space in the Zeidler Ledcor Building and a 100 m2 human research endoscopy facility in the University of Alberta Hospital.

CLINICAL TRIAL FACILITIES AND SUPPLIES

MTI has access to the CEGIIR dry lab space in the Zeidler Ledcor Building which will provide additional assistance through access to clinicians, research associates and post-doctoral fellows as well as research coordinators and clinical exam space to see patients. The clinical research unit of CEGIIR is linked to the Northern Alberta Clinical Trials Research Center (NACTRC). Furthermore, the company has access to CEGIIR's biobank that will maintain an accurate library of human samples (blood, urine and tissue) which will catalogue in detail and tag the essential patient and disease data from MTI's clinical trials.

NANUC

MTI leverages the existing equipment available at NANUC (The National High Field Nuclear Magnetic Resonance Centre). NANUC has provided the international NMR community with scientific and technical excellence to over 100 principle investigators from 40 institutions world wide. It is also home to the University of Alberta's metabolomics initiatives. It has been host to various independent research initiatives, along with a portion of the Human Metabolome Project, and is the chosen service supplier for NMR support for Chenomx Inc. Along with the 800 MHz NMR, NANUC is also home to both a 600 MHz and 500 MHz NMR spectrometers. Our metabolomics experiments take advantage of the 600 MHz spectrometer paired with a 5mm HX probe. Accompanying the 600 MHz NMR is a Varian 768 AS sample handling robot capable of handling 768 samples at a time. The Varian 768 AS has the capability to acquire 7 samples/hour of operation.

THE METABOLOMICS INNOVATION CENTRE (TMIC)

Through a long-term strategic collaboration with TMIC, MTI has extended the metabolomics analysis platforms to LC-MS, GC-MS, in addition to NMR. TMIC is a nationally-funded core facility that has a unique combination of infrastructure and personnel to perform a wide range of cutting-edge metabolomic studies for clinical trials research, biomedical studies, bioproducts studies, nutrient profiling and environmental testing. TMIC has access to more than $26 million in state-of-the-art metabolomics infrastructure. It is supported by a team of lab managers, NMR spectroscopists, mass spectrometrists, chemists, computer scientists, statisticians and bioinformaticians. TMIC is capable of identifying and quantifying up to 2000 different chemicals from certain biological samples. This is approximately 5X more comprehensive than any other service currently available.

MACHINE LEARNING

Alberta Machine Intelligence Institute (Amii) provides MTI with an expertise in machine learning techniques that are designed to handle large and complex data sets. Amii is the Alberta Machine Intelligence Institute, a research lab at the University of Alberta previously known as the Alberta Innovates Centre for Machine Learning (AICML). Amii specializes in the research and development of machine learning technologies, including their application in artificial intelligence with experts hail from the Department of Computing Science, the Faculty of Medicine & Dentistry and the School of Public Health.